Hydroperoxides of Limonene and Linalool

Linalool is a naturally occurring terpene alcohol chemical found in many flowers and spice plants with many commercial applications, the majority of which are based on its pleasant scent.

Limonene takes its name from the lemon, as the rind of the lemon contains considerable amounts of this compound, which contributes to the odor. 

Both fragrances are very common in cosmetic products, such as perfumes and creams. The hydroperoxides are formed when Limonene and Linalool are exposed to sunlight and air. 

Research including multicenter and repeated open application test (ROAT) studies, where Chemotechnique Diagnostics has been involved, have shown that the hydroperoxides are the molecules that cause the allergies – not the unoxidized perfume ingredient. 

Swedish national television news broadcasted, in September 2013, two reports covering an outbreak of allergic contact dermatitis caused by these haptens. The videos (with english subtitles) can be watched below this text. 

Title: Common fragrance substances gives contact dermatitis

A case report of a masseur with contact dermatitis towards hydroperoxides is presented. 
Dr. Ann-Therese Karlberg is talking about the new data that now are available.
Dr. Johanna Bråred-Christensson is discussing what you should do to avoid these problems and what to do if you should suspect contact dermatitis. 

Title: Massage oil elicits eczema / contact dermatitis